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Hainantoxin-IV（海南捕鳥蛛毒素-IV）
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：12HTX001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-29
- 訪 問 量：1546
產(chǎn)品介紹
Hainantoxin-IV（海南捕鳥蛛毒素-IV）
Selective blocker of TTX-S VGSC(電壓門控鈉離子通道TTX-S選擇性阻斷劑)
Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spiderOrnithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.
Hainantoxin-IV技術(shù)資料
氨基酸序列：
Glu-Cys2-Leu-Gly-Phe-Gly-Lys-Gly-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Asn-Leu-Val-Cys24-Ser-Arg-Lys-His-Arg-Trp-Cys31-Lys-Tyr-Glu-Ile-NH2
二硫鍵： Disulfide bonds between Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31
長(zhǎng)度 (aa)： 35
分子式：C166H257N53O50S6
分子量： 3987.6 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：Not available
來源：Synthetic
純度：> 97%
產(chǎn)品信息
12HTX001-00100 | Hainantoxin IV | 0.1mg |
12HTX001-00500 | Hainantoxin IV | 0.5mg |
12HTX001-01000 | Hainantoxin IV | 1mg |
